Okay, speaking of schools, I had a vague idea for a story where the protagonist would be a teacher or a principal or an owner of a private school and could do anything they want with it. But I guess it would also work well or maybe even better as a concept for a game.

So, you're in a position of power in school, probably an owner of a private school and you can do whatever you want with it in sandbox mode, then maybe there's also a career mode where you have to take care of your budget as well. Maybe even start as a teacher controlling only one class with lots of limitations then get promoted to a principal controlling all of the school (or maybe being a teacher can be a tutorial level).
Basically the gameplay consists of setting up all kind of rules for the school and then running the simulation to see how it plays out. The idea is to have many many possible rules and have emergent gameplay from how you combine them in your particular case (we have Rockstar's budget, right? So it should be possible). The rules come in all sorts of flavors from pretty regular like if you enforce uniforms to more quirky like having those uniforms include collars and cat ears to erotic like having those unifroms be bottomless and to involving outrigth sex and to involving guro (actually, guro isn't really necessary for this game, but since we're on gurochan...) You can also set each rule to apply to everyone or only a particular category of students (boys, girls, A students, D students, first year students, students in sport clubs, etc) You can also have rules for enrollment, which can be as simple as being an only girls', only boys' or co-ed school, to combinations like: have only reach girls and only boys bought from slave market; or have only straight A boys and only most cute girls. You can also decide punishments for each rule if it is broken, which can range from no punishment to cruel execution in front of the whole school. In career mode you unlock more quirky rules and more severe punishments as you go, either as your school's ratings grow and so you can afford being more special, or as your students get more used to quirky stuff. Yeah, actually that sounds good: if you just outright oblige the girls to have sex with male teachers in an otherwise normal school, there will be protests, but if you have them go to the school in the nude for some months before that, then they'll show more acceptance. Of course, in sanbox mode you can tweak their acceptance as well and start with a school that already sees nothing wrong with executing random students at teacher's whim and as the teacher walks by and starts killing on of the student, the others they were chatting with won't even flinch. Ah, and you can also have rules for your teachers, and unlike students you can hire each teacher personally (but in sandbox mode you can design individual students too, you just probably don't want to do it for every student). Speaking of which, you can probably choose the size of your school as well (or maybe actually design the whole building like in sims or something).

So, let's think of some rules and how they can effect the gameplay.

For example, you can have a rule for all female students to be naked.
It will make female students feel embarrassed at first until they get used to it, so their academic success will lower in a short term. Some might even catch a cold, especially if you introduce this rule in winter (btw maybe you can also choose climate at the start of the game). But eventually they will acclimatize and actually improve their health in the longer term. Which will both help them with studies (less absence -> better studying) and sports, which in turn will benefit the school's ratings and through that your budget and options.
On the other hand male students will react too, being aroused by the constant presence of naked girls, which will distract them from studying and also lead to lesser grades. They will probably also get used eventually, but you can help them by allowing masturbation in school, or maybe even let them freely use the girls for sex (each of which should have complex consequences of their own). Or, if you're feeling dictatorial, you might set a harsh punishment for masturbation and/or sex in school instead. If you have such a punishment be executed by the girls, you will raise the girls' self-confidence and they won't even see their own nudity as humiliating, but empowering instead, further bettering their grades at the cost of those of poorly treated boys. On the other hand it will also teach the boys humility which might also be beneficial in the long run.
Anyway, the game should let you exploit benefit from being benevolent or violent or favoring some categories of students more then others, as long as you do it wisely. Maybe if you're being all violent with children, you can get budget from selling them to slave market instead of from having good rating, and then buy the rating by money instead?
Also, there's a trick to this rule: if you start installing it from youngest classes (smth like "forced nudity for (female) and (enrollment year > 20XX)") when the children are still innocent, they won't react to it as much and then will already be used to it by the time they're interested in sex. So they won't be distracted by seeing each other naked any more then students in a normal school by seeing clothed students of opposite gender.

If you're a boarding school, you can decide how your dorms work too.
For example, you can have an elite one-person apartment for each of your students (if you can afford it or play in sandbox) or just for the best ones.
Or you can have barracks where the whole class sleeps in one room (divide boys from girls or not at your wish... speaking of which, you can probably also have individual classes consist only of boys or only of girls if you wish) to make them feel like they're all one big family.
Or you can have two-person rooms and have each room be assigned to a pair of a boy and a girl. Or you can just allow boys and girls to share a room, but not assign them specifically, leaving in to chance which room will get populated with two boys, two girls or a boy and a girl.
Or you can have four-person rooms and assign 1 girl and 3 boys in each, given you have such a distribution of genders, and see what happens.

You can declare that being absent from classroom for toilet hurts the studies and have a toiler installed right in the classroom, so that the students can use it without missing parts of the lesson. You can choose to install it in the back of the classroom or in the front so that they do it in front of everyone's eyes. And then see how in the long run (after everyone is used to it) it not only helps the studies, but by students having seen every side of each other will make them more empathetic to each other, reinforcing the feeling that they're all one big family. These rules apply separately for number one and number two of course, in case you don't have the number two in your classroom.
Or you can make the boys use girls as urinals, but unless you play in sandbox, that'll require some preparations before such a rule can be accepted.
Or you can make them all just pee wherever they happened to be when they felt the urge, be it on their seat in the middle of the class, at the blackboard or right in their bed at the dorms. Or in the corridor as they just walk through it.

Serve cum-covered food and pee-based drinks in the cafeteria. Or serve shit if you're into it.
Let the boys in each class vote for a girl who will become a cumdumpster for them, or appoint one by yourself.
Introduce lessons on having sex.
Introduce sex while having lessons.
Accept rich girls and boys bought from the slave market to your school, and then make the girls be slaves to the boys.
Or just have boys wear girls' uniforms.
Or go the guro way and make the anatomy lessons have vivisection of the wort studying female student. Or best studying male student. Or a green-eyed student with the reddest hair. Or just someone of your pick.
Or introduce fighting to death to your P.E. lessons.
Or have a sex'n'snuff festival, that's always fun.
Whatever the school of your dreams is, you should be able to make one in this game. Or mod it in.

Basically the game should have a very complex character system where characters can have all kinds of traits and parameters, a super robust AI behaving on those traits and parameters, including those you can mod in, and then you should be able to set up rules based on those (so a big and adjustable list of rules, which you can also add with mods). "Apply rule (Wear cat-tail butt-plugs) for (gender = female) and ((hair = dark) or (hair = purple)) and (boobs < B) when (in_school)" kind of stuff. And then the characters will react to it via simulation, so you don't know how a particular rule will play out combined with all the other rules you set up for this playthrough, and that's where the fun is.