You know what would be hot? Remove her clit, maybe after alittle forplay but not letting her reach climax. Then after she stops screaming, and soaks in she will never feel between her legs again, stimulate her pleasure center directly. Fire all the neurons in her nucleus accumbent. First gently, then stronger and stronger. All the way to orgasm. With her coming down being those neurons dying. Forever incapable of ever feeling any pleasure at all.

It could be fun to cut out a girls hippocampus so every hour is new to her. Letting her experience brain torture and stimulation/manipulation for the first time, over and over again.

Or maybe overdrive her fear center and shock her occipital lobe into seeing what she is thinking. But without a working motor cortex she is helpless to fight her imagination.