Okay, talking of skinless girls reminded be of an idea of mine. I imagined it with Ayanami Rei, but it can work with some other charachter too. Whether she's dripping blood everywhere I'll leave for whoever might actually adopt this idea to decide.

There will be developed a way to let a person survive without skin (like if they suffered a severe burn and skin is irreparable; all the skin, both burnt and healthy parts, would have to be removed for that), but that would not remove the pain. And something like this would happen to Rei, probably in one of the battles with Angels, so she would be the first one on whom this technology will be applied. The story would take a form of the interview where Rei would be asked about living without skin (and clothes). Rei would tell that the only sensation left for her is pain. Just existing hurts as air touches her skinless body. Standing hurts her feet, sitting hurts her butt and lying on the bed hurts most of her body. Simplest things hurt like hell. The world that used to be a dull and boring place is now so intense and interesting. Rei rediscoveres it like a little child. How would it hurt to touch something hot? To touch something cold? To take a shower? To swim? To lay on a sandy beach? To hug? Or maybe to spar? Out of a shut-in Rei turns into an enthusiastic girl who loves trying new things and how they feel(hurt). She recommens to everyone to go for such a surgery even if they don't need it to save their live, cause it would save their life from boredom.